Manipulating nuclear architecture
نویسندگان
چکیده
منابع مشابه
Nuclear Architecture and Epigenetics of Lineage Choice
Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...
متن کاملnuclear architecture and epigenetics of lineage choice
differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. a number of studies have reported the effects of biochemical modifications of chromatin (dna and chromatin proteins) on the regulation of transcription. although, these studies are able to explain how transcription of a given gene is regulated (toward activation...
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The dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important determinant of cell function. Recent studies point to a crucial role of RNA as an architectural factor for shaping the genome and its nuclear environment. Here, we outline general principles by which RNA organizes functionally different nuclear subcompartments in mammali...
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www.landesbioscience.com Cell Cycle 3455 The centromere is a unique region of the chromosome that defines the site of kinetochore assembly and is essential for the faithful segregation of the sister chromatids into the 2 daughter cells. While the kinetochore only forms as a transient structure during mitosis, the centromere persists as a stable domain throughout the cell cycle, bound by protein...
متن کاملChromatin architecture and nuclear RNA.
The maintenance of normal chromatin morphology requires ongoing RNA synthesis. We have examined the role of RNA in chromatin organization, using selective detergent extraction of cells, RNA synthesis inhibitors, and enzymatic digestion of nuclear RNA. Comparison of extracted and unextracted cells showed that the important features of chromatin architecture were largely unchanged by the extracti...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2014
ISSN: 0959-437X
DOI: 10.1016/j.gde.2013.10.014